@article{10902/21207,
year = {2020},
month = {7},
url = {http://hdl.handle.net/10902/21207},
abstract = {We aimed to study the association between occupational exposure to pesticides and
chronic lymphocytic leukemia (CLL) in Spain. Occupational exposure to pesticides (four insecticides,
four herbicides and two fungicides) was evaluated using a job-exposure matrix for the Spanish
population (MatEmESp) among 302 CLL cases and 1567 population controls in five regions of Spain,
2010?2013. Cumulative exposure scores (CES) were obtained by summing across the exposed jobs
the product of prevalence, intensity and duration of exposure to each active substance. Principal
components analysis (PCA) and logistic regression models adjusted for age, sex, region, education and
occupational exposure to solvents were used. Around 20% of controls and 29% of cases were exposed
to one or more pesticides. Compared to non-exposed, subjects in the highest tertile (3rd tertile) of
CES of insecticides, herbicides, fungicides were more likely to have CLL [OR (95% CI), P-trend;
2.10 (1.38; 3.19), 0.002; 1.77 (1.12; 2.80), 0.12; and 1.67 (1.06; 2.64), 0.10, respectively). Following PCA,
the first component (PC1, explaining 70% of the variation) equally led by seven active substances
(the insecticide pyrethrin, all herbicides, all fungicides) was associated with a 26% higher odds of
having CLL for 1-standard deviation increase in PC1 (95% CI: 1.14 to 1.40). These results confirm
previous associations between CLL and exposure to pesticides and provide additional evidence
by application groups and active substance. However, more research is needed to disentangle
independent e ects of individual active substances.},
organization = {We thank CERCA programme/Generalitat de Catalunya for institutional support. This work was
supported by Spanish Ministry of Economy and Competitiveness—Carlos III Institute of Health co-funded by
FEDER funds/European Regional Develpment Fund (ERDF)—A way to build Europe (PI08/1770, PI08/0533,
PI08/1359, PS09/00773-Cantabria, PI11/01403, PI11/02213, PI14/1219, PI15/00966, PI17/01280, RTIC RD06/0020/0095,
RD12/0036/0036, SV-09-CLINIC-1 and CIBERESP), by Juan de la Cierva (IJCI-2016-29502), by the Fundación
Marques de Valdecilla (API 10/09), by Obra Social CAJASTUR (SV-CAJASTUR-1), by the Recercaixa (2010ACUP
00310 and with the support of the Secretariat for Universities and Research of the Ministry of Business and
Knowledge of the Government of Catalonia (2017SGR1085). The ICGC CLL-Genome Project was funded
by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III
(ISCIII), PMP15/00007 and CIBERONC del ISCIII. ISGlobal is a member of the CERCA Programme, Generalitat
de Catalunya.},
publisher = {MDPI},
publisher = {Int. J. Environ. Res. Public Health 2020, 17(14), 5174},
title = {Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study},
author = {Benavente, Yolanda and Costas, Laura and Rodríguez Suarez, Marta Maria and Alguacil, Juan and Santibáñez Margüello, Miguel and Vila, Javier and Robles, Claudia and Alonso, Esther and Banda, Esmeralda de la and Gonzalez Barca, Eva and Dierssen Sotos, Trinidad and Gimeno Vázquez, Eva and Aymerich, Marta and Campo, Elias and Jiménez Moleón, José J. and Marcos Gragera, Rafael and Castaño Vinyals, Gemma and Aragonés, Nuria and Pollán, Marina and Sanjose, Silvia de},
}