@article{10902/21182,
year = {2020},
url = {http://hdl.handle.net/10902/21182},
abstract = {Background and objectives: Psoriatic arthritis (PsA) is associated with several comorbidities,
including among others an increased risk of cardiovascular (CV) disease, atherosclerosis, metabolic
syndrome, hypertension dyslipidemia, and diabetes. The purpose of the present study was to
determine how the number of CV risk factors correlates with disease related data such as disease
activity. Materials and Methods: Cross-sectional study that encompassed 305 patients who fulfilled
the CASPAR criteria for PsA were assessed for lipid profile, disease activity measurements, and the
presence of six traditional CV risk factors (diabetes mellitus, dyslipidemia, hypertension, obesity,
chronic kidney disease, and smoking status). A multivariable regression analysis, adjusted for age,
sex, and disease duration, was performed to evaluate if the number of classic CV risk factors was
independently related with specific features of the disease, including disease activity. Results: Disease
duration was found to be higher, after adjustment for age and sex, in patients with 1 or 2, and 3 or
higher CV factors, compared to those patients without CV risk factors. Similarly, DAPSA (Disease
Activity in PSoriatic Arthritis score) was found to be independently upregulated in patients with a
higher number of CV risk factors. In this sense, as DAPSA score increases the odds ratio (OR) of having
1 or 2 (OR 1.12 (95% confidence interval (CI) 1.03?1.21), p = 0.010), and 3 or higher (OR 1.15 (95% CI
1.04?1.26), p = 0.004) CV factors was significantly higher compared to no CV risk factors category.
This was independently found after adjustment for age, sex, and disease duration. Conclusions:
PsA patients with a higher number of CV risk factors exhibit an upregulated disease activity compared
to those without them. This is independent of disease duration and other demographics factors},
organization = {This research was funded by the Instituto de Salud Carlos III (ISCIII) (Fondo de Investigación Sanitaria
grants PI06/0024, PI09/00748, PI12/00060, PI15/00525, PI18/00043) and the ISCIII RETICS programs (RD12/0009 and
RD16/0012).},
publisher = {MDPI},
publisher = {Medicina 2020, 56, 415},
title = {The Number of Traditional Cardiovascular Risk Factors Is Independently Correlated with Disease Activity in Patients with Psoriatic Arthritis},
author = {Iván Ferraz-Amaro and Diana Prieto-Peña and Natalia Palmou-Fontana and David Martínez-López and Laura de Armas-Rillo and Alicia García-Dorta and Belén Atienza-Mateo and Ricardo Blanco and Susana Armesto and González-Gay Mantecón, Miguel Ángel},
}