@article{10902/20700,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10902/20700},
abstract = {Solid lipid particles (SLPs) can sustainably encapsulate and release therapeutic agents over long periods, modifying their biodistribution, toxicity, and side effects. To date, no studies have been reported using SLPs loaded with doxorubicin chemotherapy for the treatment of metastatic cancer. This study characterizes the effect of doxorubicin-loaded carnauba wax particles in the treatment of lung metastatic malignant melanoma in vivo. Compared with the free drug, intravenously administrated doxorubicin-loaded SLPs significantly reduce the number of pulmonary metastatic foci in mice. In vitro kinetic studies show two distinctive drug release profiles. A first chemotherapy burst-release wave occurs during the first 5 h, which accounts for approximately 30% of the entrapped drug rapidly providing therapeutic concentrations. The second wave occurs after the arrival of the particles to the final destination in the lung. This release is sustained for long periods (>40 days), providing constant levels of chemotherapy in situ that trigger the inhibition of metastatic growth. Our findings suggest that the use of chemotherapy with loaded SLPs could substantially improve the effectiveness of the drug locally, reducing side effects while improving overall survival.},
organization = {This research was funded by the European Regional Development Fund (ERDF) and the
Spanish MINECO Refs. PI16/00496 (AES 2016), PI19/00349 (AES 2019), and DTS19/00033; IDIVAL
Refs. INNVAL17/11 and INNVAL19/12. J.G. and M.B.-L. also acknowledge financial support
from the Fundação para a Ciência e a Tecnologia and the ERDF through NORTE2020 (2014–2020
North Portugal Regional Operational Program) through the projects UTAP-EXPL/NTec/0038/2017
(NANOTHER) and NORTE-01-0145-FEDER-031142 (MAGTARGETON). Nano2clinics COST Action
CA17140.},
publisher = {MDPI},
publisher = {Pharmaceutics, 2021,13(1), 93},
title = {Solid lipid particles for lung metastasis treatment},
author = {Valdivia Fernández, Lourdes María and García Hevia, Lorena and Bañobre López, Manuel and Gallo, Juan and Valiente Barroso, Rafael and López Fanarraga, Mónica},
}