@article{10902/18961,
year = {2019},
url = {http://hdl.handle.net/10902/18961},
abstract = {Background. We analyzed the prevalence, etiology, and risk factors of culture-positive preservation fluid and their impact on the management of solid organ transplant recipients.
Methods. From July 2015 to March 2017, 622 episodes of adult solid organ transplants at 7 university hospitals in Spain were prospectively included in the study.
Results. The prevalence of culture-positive preservation fluid was 62.5% (389/622). Nevertheless, in only 25.2% (98/389) of the cases
were the isolates considered ?high risk? for pathogenicity. After applying a multivariate regression analysis, advanced donor age was the main associated factor for having culture-positive preservation fluid for high-risk microorganisms. Preemptive antibiotic therapy was given to 19.8% (77/389) of the cases. The incidence rate of preservation fluid?related infection was 1.3% (5 recipients); none of these patients had received preemptive therapy. Solid organ transplant (SOT) recipients with high-risk culture-positive preservation fluid receiving
preemptive antibiotic therapy presented both a lower cumulative incidence of infection and a lower rate of acute rejection and graft loss compared with those who did not have high-risk culture-positive preservation fluid. After adjusting for age, sex, type of transplant, and prior graft rejection, preemptive antibiotic therapy remained a significant protective factor for 90-day infection.
Conclusions. The routine culture of preservation fluid may be considered a tool that provides information about the contamination of the transplanted organ. Preemptive therapy for SOT recipients with high-risk culture-positive preservation fluid may be useful to avoid preservation fluid?related infections and improve the outcomes of infection, graft loss, and graft rejection in transplant patients.},
publisher = {Oxford University Press},
publisher = {Open Forum Infectious Diseases, Volume 6, Issue 6, June 2019, ofz180},
title = {The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study},
author = {Oriol, I. and Sabe, N. and Càmara, J. and D. Berbel and Ballesteros Sanz, María Ángeles and Escudero, R. and Lopez-Medrano, F. and Linares, L. and Len, O. and Silva, J. T. and Oliver, E. and Soldevila, L. and Pérez-Recio, S. and Guillem, L. L. and Camprubí, D. and LLadó, L. and Manonelles, A. and González-Costello, J. and Domínguez, M. A. and Fariñas Álvarez, María del Carmen},
}