@article{10902/18952,
year = {2019},
url = {http://hdl.handle.net/10902/18952},
abstract = {Background: we aimed to assess the influence of metabolic syndrome on fibrosis regression (using liver-stiffness measurement (LSM) and serological scores) and the relationship with the expression of lysyl oxidase-like-2 as a potential goal of antifibrotic therapy.

Methods: We included 271 patients treated with Direct Antiviral Therapy (DAAs) in our hospital who achieved a sustained virological response (SVR); physical examination, blood tests, and LSM were made at baseline (B) and 24 months (24 M) after SVR. Hemodynamic studies and transjugular liver biopsies were performed on 13 patients.

Results: At B, 68 patients were F1 (25.1%); F2 n = 59 (21.7%); F3 n = 44 (16.05%); and 100 were F4 (36.9%). Although the LSM (absolute value) improved in 82% of patients (n = 222), it progressed in 17.5% of patients (n = 48). At 24 M, 48 patients met the metabolic syndrome (MetS) criteria and there was an increase in patients with a BMI of >25 kg/m2 (p < 0.001). At B and 24 M, a BMI of >25 kg/m2 is a risk factor for significant fibrosis or steatosis at 24 M (p < 0.05) and progression on LSM (p < 0.001), as well as MetS at B and 24 M (OR 4.1 IC (1.4-11.7), p = 0.008; and OR 5.4 IC (1.9-15.4), p = 0.001, respectively). Regarding the correlation between LSM and the liver biopsy, we found that only six out of 13 patients had a matching LSM and biopsy. We found a statistically significant decrease in LOXL2 levels at 24 M with respect to B (p < 0.001) with higher serological value in patients with elastography of >9 kPa vs. <9 kPa (p = 0.046).

Conclusion: Regression of LSM was reached in 82% of patients. Downregulated LOXL2 was demonstrated post-SVR, with overexpression in cirrhotic patients being a potential therapy goal in selected patients.},
organization = {Funding: This study was supported by the Health Research Institute Marqués de Valdecilla. IDIVAL. Santander. NEXT VAL15/12 grant to Dra Angela Puente Sanchez: Regresión de la fibrosis hepática tras erradicación del virus de la hepatitis C. Papel de la LOXL2.
Acknowledgments: This study has been supported by competitive grants from the Instituto de Salud Carlos III (Spanish Ministries of Health and of Economy; PIE15/00079 and PI15/02138).},
publisher = {MDPI AG},
publisher = {J Clin Med
. 2019 Aug 17;8(8):1242},
title = {Changes in Circulating Lysyl Oxidase-Like-2 (LOXL2) Levels, HOMA, and Fibrosis after Sustained Virological Response by Direct Antiviral Therapy},
author = {Puente, Angela and Fortea, Jose Ignacio and Posadas, Miguel and García Blanco, Agustín and Rasines, Laura and Cabezas González, Joaquín and Arias Loste, María Teresa and Llerena, Susana and Iruzubieta, Paula and Fábrega García, Emilio and Crespo García, Javier},
}