@article{10902/18944,
year = {2019},
url = {http://hdl.handle.net/10902/18944},
abstract = {Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians. Frequencies and AD-associated effects of variants differ across ethnicities. To start filling the gap on AD genetics in South America and assess the impact of these variants across ethnicity, we studied these variants in Argentinian population in association with ancestry. TREM2 (rs143332484 and rs75932628), PLCG2 (rs72824905), and ABI3 (rs616338) were genotyped in 419 AD cases and 486 controls. Meta-analysis with European population was performed. Ancestry was estimated from genome-wide genotyping results. All variants show similar frequencies and odds ratios to those previously reported. Their association with AD reach statistical significance by meta-analysis. Although the Argentinian population is an admixture, variant carriers presented mainly Caucasian ancestry. Rare coding variants in TREM2, PLCG2, and ABI3 also modulate susceptibility to AD in populations from Argentina, and they may have a European heritage.},
organization = {Acknowledgements: This work was supported by grants from the International Society for Neurochemistry (ISN) and Alexander von Humboldt Foundation (to M.C.D.); Agencia Nacional de Promoción Científica y Tecnológica (PBIT/09 2013, PICT-2015-0285 and PICT-2016-4647 to L.M.; PICT-2014-1537 to M.C.D.); GENMED Labex and JPND PERADES grant; and JPND EADB grant (German Federal Ministry of Education and Research, BMBF: 01ED1619A).},
publisher = {Nature Pub. Group},
publisher = {Transl Psychiatry
. 2019 Jan 31;9(1):55},
title = {Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease},
author = {Dalmasso, Maria Carolina and Brusco, Luis Ignacio and Olivar, Natividad and Muchnik, Carolina and Hanses, Claudia and Milz, Esther and Becker, Julian and Heilmann-Heimbach, Stefanie and Hoffmann, Per and Prestia, Federico A. and Galeano, Pablo and Sanchez Avalos, Mariana Soledad and Martinez, Luis Eduardo and Carulla, Mariana Estela and Azurmendi, Pablo Javier and Liberczuk, Cynthia and Fezza, Cristina and Sampaño, Marcelo and Fierens, Maria and Sánchez-Juan, Pascual},
}