@article{10902/1799,
year = {2011},
month = {6},
url = {http://hdl.handle.net/10902/1799},
abstract = {BACKGROUND: Mild cognitive impairment (MCI) is a heterogeneous clinical entity that comprises the prodromal phase of Alzheimer's disease (Pr-AD). New biomarkers are useful in detecting Pr-AD, but they are not universally available. We aimed to investigate baseline clinical and neuropsychological variables that might predict progression from MCI to AD dementia.

METHODS: All patients underwent a complete clinical and neuropsychological evaluation at baseline and every 6 months during a two-year follow-up period, with 54 out of 109 MCI patients progressing to dementia (50 of them progressed to AD dementia), and 55 remaining as stable MCI (S-MCI).

RESULTS: A combination of MMSE and California Verbal Learning Test Long Delayed Total Recall (CVLT-LDTR) constituted the best predictive model: subjects scoring above 26/30 on MMSE and 4/16 on CVLT-LDTR had a negative predictive value of 93.93% at 2 years, whereas those subjects scoring below both of these cut-off scores had a positive predictive value of 80.95%.

CONCLUSIONS: Pr-AD might be distinguished from S-MCI at baseline using the combination of MMSE and CVLT-LDTR. These two neuropsychological predictors are relatively brief and may be readily completed in non-specialist clinical settings.},
publisher = {BioMed Central},
publisher = {BMC Neurology. 2011 Jun 24;11:78},
title = {Detection of early Alzheimer's disease in MCI patients by the combination of MMSE and an episodic memory test},
author = {Pozueta, Ana and Rodríguez Rodríguez, Eloy Manuel and Vázquez Higuera, José Luis and Mateo Fernández, José Ignacio and Sánchez-Juan, Pascual and González Pérez, Soraya and Berciano, José Ángel and Combarros Pascual, Onofre},
}