@article{10902/17879,
year = {2019},
url = {http://hdl.handle.net/10902/17879},
abstract = {Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.},
organization = {This research was funded by the Spanish Ministry of Economy and Competitiveness—Carlos III Institute of Health cofunded by FEDER funds/European Regional Development Fund (ERDF)—a way to build Europe (grants PI17/01280, PI11/01810, PI14/01219, PI11/02213, PI09/1662, PI15/00966, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056, Rio Hortega CM13/00232, Juan de la Cierva de Incorporacion IJCI-2016-29502 and SV-09-CLINIC-1), Centro de Investigación Biomédica en Red: Epidemiología y Salud Pública (CIBERESP, Spain) and Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme/Generalitat de Catalunya for institutional support(2017SGR1085), and European Regional Development Fund-ERDF/FEDER. The ICGC CLL-Genome Project was funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII), PMP15/00007 which is part of Plan Nacional de I+D+I and is co-financed by the ISCIII-Sub-Directorate General for Evaluation and the European Regional Development Fund (FEDER-“Una manera de Hacer Europa”) and CIBERONC. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.},
publisher = {MDPI},
publisher = {Nutrients. 2019 Dec 23;12(1). pii: E48},
title = {The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study},
author = {Flores, José Carlos and Gracia-Lavedan, Esther and Benavente, Yolanda and Amiano, Pilar and Romaguera, Dora and Costas, Laura and Robles, Claudia and Gonzalez-Barca, Eva and Banda, Esmeralda de la and Alonso, Esther and Aymerich, Marta and Campo, Elias and Dierssen Sotos, Trinidad and Marcos-Gragera, Rafael and Rodriguez-Suarez, Marta María and Solans, Marta and Gimeno, Eva and Garcia Martin, Paloma and Aragones, Nuria and Shivappa, Nitin},
}