@article{10902/1707,
year = {2004},
month = {10},
url = {http://hdl.handle.net/10902/1707},
abstract = {Metabolic alterations such as insulin resistance are thought to underlie the endothelial dysfunction and low grade inflammation found in morbid obesity. Twenty-six morbidly obese patients, aged 39.0 +/- 10.0 (mean +/- sd), were evaluated before and 4.2 +/- 0.8 months after bariatric surgery. A marked increment in the insulin sensitivity index (S(I)) and the endothelium-dependent vasodilatory response in a dorsal hand vein was observed after weight loss following bariatric surgery. Circulating levels of E-selectin, P-selectin, plasminogen activator inhibitor-1, and von Willebrand factor, which were higher than those in the control group, decreased significantly after surgery. Plasma vascular cell adhesion molecule-1, angiotensin-converting enzyme, intercellular adhesion molecule-1, thrombomodulin, and plasma and intraplatelet cGMP levels did not change after weight loss. All inflammatory markers were higher in morbidly obese patients. After surgery, C- reactive protein and sialic acid diminished, whereas circulating levels of IL-6, TNF-alpha, and its soluble receptors did not. Positive correlations were found between changes in adiposity and S(I) and changes in C-reactive protein and between changes in sialic acid and changes in endothelial function. In conclusion, a marked improvement in S(I), endothelial function, and low grade inflammation was observed in the weight-losing, morbidly obese patients after bariatric surgery. S(I) and adiposity appear to play roles in obesity-related, low grade inflammation that contribute to the endothelial dysfunction observed in morbid obesity.},
publisher = {Endocrine Society},
publisher = {Journal of Clinical Endocrinology and Metabolism. 2005 Jan;90(1):316-22. Epub 2004 Oct 26},
title = {Effects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery},
author = {Vázquez, Luis Alberto and Pazos Toral, Fernando and Berrazueta Fernández, José Ramón de and Fernández-Escalante Moreno, José Carlos and García Unzueta, María Teresa and Freijanes Parada, Julio and Amado Señarís, José Antonio},
}