@article{10902/16887,
year = {2019},
month = {3},
url = {http://hdl.handle.net/10902/16887},
abstract = {Multiple-drug resistance in human cancer is a major problem. To circumvent this issue, clinicians combine several drugs. However, this strategy could backfire resulting in more toxic or ineffective treatments. Carbon nanotubes (CNTs), and particularly multi-walled nanotubes (MWCNTs), display intrinsic properties against cancer interfering with microtubule dynamics and triggering anti-proliferative, anti-migratory and cytotoxic effects in vitro that result in tumor growth inhibition in vivo. Remarkably, these effects are maintained in tumors resistant to traditional microtubule-binding chemotherapies such as Taxol®. In the view of these properties, we investigate the use of MWCNTs in the development of active-by-design nanocarriers, attempting to enhance the effect of broadly-used chemotherapies. We compare the cytotoxic and the anti-tumoral effect of 5-Fluorouracil (5-FU) -an antimetabolite treatment of various forms of cancer- with that of the drug physisorbed onto MWCNTs. Our results demonstrate how the total effect of the drug 5-FU is remarkably improved (50% more effective) when delivered intratumorally coupled to MWCNTs both in vitro and in vivo in solid tumoral models. Our results demonstrate how using MWCNTs as anti-cancer drug delivery platforms is a promising approach to boost the efficacy of traditional chemotherapies, while considerably reducing the chances of resistance in cancer cells.},
organization = {This work was founded by the following sources: Spanish MINECO, Instituto de Salud Carlos III, the European Union FEDER funds under Projects ref. PI16/00496 (AES 2016), MAT2015-69508-P, NanoBioApp Network (MINECO-17-MAT2016-81955-REDT) European Union (European Regional Development Fund-ERDF) and INNVAL 16/15, INNVAL 17/11.},
publisher = {Impact Journals},
publisher = {Oncotarget, 2019, 10(21), 2022-2029},
title = {Multi-walled carbon nanotubes complement the anti-tumoral effect of 5-Fluorouracil},
author = {González Lavado, Eloisa and Valdivia Fernández, Lourdes María and García Castaño, Almudena and González Martínez, Fernando and Pesquera González, Carmen and Valiente Barroso, Rafael and López Fanarraga, Mónica},
}