@article{10902/16127,
year = {2018},
month = {6},
url = {http://hdl.handle.net/10902/16127},
abstract = {Obesity is an epidemic disease characterized by chronic low-grade inflammation associated with a dysfunctional fat mass. Adipose tissue is now considered an extremely active endocrine organ that secretes cytokine-like hormones, called adipokines, either pro- or anti-inflammatory factors bridging metabolism to the immune system. Leptin is historically one of most relevant adipokines, with important physiological roles in the central control of energy metabolism and in the regulation of metabolism-immune system interplay, being a cornerstone of the emerging field of immunometabolism. Indeed, leptin receptor is expressed throughout the immune system and leptin has been shown to regulate both innate and adaptive immune responses. This review discusses the latest data regarding the role of leptin as a mediator of immune system and metabolism, with particular emphasis on its effects on obesity-associated metabolic disorders and autoimmune and/or inflammatory rheumatic diseases.},
organization = {OG is Staff Personnel of Xunta de Galicia (Servizo Galego de
Saude, SERGAS) through a research-staff stabilization contract
(ISCIII/SERGAS). VF is a “Sara Borrell” Researcher funded by
ISCIII and FEDER. RG is a “Miguel Servet” Researcher funded
by Instituto de Salud Carlos III (ISCIII) and FEDER. OG, MG-G,
and RG are members of RETICS Program, RD16/0012/0014
(RIER: Red de Investigación en Inflamación y Enfermedades
Reumáticas) via Instituto de Salud Carlos III (ISCIII) and
FEDER. The work of OG and JP (PIE13/00024 and PI14/00016,
PI17/00409), and RG (PI16/01870 and CP15/00007) was funded
by Instituto de Salud Carlos III and FEDER. OG is a beneficiary of
a project funded by Research Executive Agency of the European
Union in the framework of MSCA-RISE Action of the H2020
Program (Project No. 734899). The funders had no role in study
design, data collection, and analysis, decision to publish, or
preparation of the manuscript.},
publisher = {Frontiers Media},
publisher = {Front. Physiol. 9:640},
title = {Obesity, Fat Mass and Immune System: Role for Leptin},
author = {Francisco, Vera and Pino, Jesús and Campos Cabaleiro, Víctor and Ruiz Fernández, Clara and Mera, Antonio and González-Gay Mantecón, Miguel Ángel and Gómez, Rodolfo and Gualillo, Oreste},
}