@article{10902/13776,
year = {2018},
month = {2},
url = {http://hdl.handle.net/10902/13776},
abstract = {Osteoarthritis is a high-incidence painful and debilitating disease characterized by progressive degeneration of articular joints, which indicates a breakdown in joint homeostasis favoring catabolic processes. Biomechanical loading, associated with inflammatory and metabolic imbalances of joint, strongly contributes to the initiation and progression of the disease. Obesity is a primary risk factor for disease onset, and mechanical factors increased the risk for disease progression. Moreover, inflammatory mediators, in particular, adipose tissue-derived cytokines (better known as adipokines) play a critical role linking obesity and osteoarthritis. The present article summarizes the knowledge about the role of adipokines in cartilage and bone function, highlighting their contribution to the imbalance of joint homeostasis and, consequently, pathogenesis of osteoarthritis.},
organization = {OG and FL are Staff Personnel of Xunta de Galicia (Servizo Galego de Saude, SERGAS) through a research-staff stabilization contract (ISCIII/SERGAS). VF is a “Sara Borrell” Researcher funded by ISCIII and FEDER. RG is a “Miguel Servet” Researcher funded by Instituto de Salud Carlos III (ISCIII) and FEDER. OG, MAGG and RG are members of RETICS Programme, RD16/0012/0014 (RIER: Red de Investigación en Inflamación y Enfermedades Reumáticas) via Instituto de Salud Carlos III (ISCIII) and FEDER. FL is a member of CIBERCV (Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares). VL is a recipient of a grant from ISCIII. The work of OG (PIE13/00024, PI14/00016, and PI17/00409), FL (PI15/00681 and CB16/11/00226) and RG (PI16/01870 and CP15/00007) was funded by Instituto de Salud Carlos III and FEDER. OG is a beneficiary of the project funded by Research Executive Agency of the European Union in the framework of MSCA-RISE Action of the H2020 Programme (Project number 734899). The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.},
publisher = {Wiley},
publisher = {Journal of Orthopaedic Research, 2018, 36(2), 594-604},
title = {Biomechanics, obesity, and osteoarthritis. The role of adipokines: when the levee breaks},
author = {Francisco, Vera and Pérez, Tamara and Pino, Jesús and López, Verónica and Franco, Eloy and Alonso, Ana and González-Gay Mantecón, Miguel Ángel and Mera, Antonio and Lago, Francisca and Gómez, Rodolfo and Gualillo, Oreste},
}