@article{10902/13675,
year = {2017},
month = {11},
url = {http://hdl.handle.net/10902/13675},
abstract = {Postsynaptic 5-HT1A receptors (5-HT1AR) play an important role in anxiety and stress, although their contribution is still controversial. Previous studies report that mice overexpressing postsynaptic 5-HT1ARs show no changes in basal anxiety, though the influence of stress conditions has not been addressed yet. In this study, we used this animal model to evaluate the role of 5-HT1ARs in anxiety response after pre-exposure to an acute stressor. Under basal conditions, 5-HT1AR overexpressing animals presented high corticosterone levels and a lower mineralocorticoid/ glucocorticoid receptor ratio. After pre-exposure to a single stressor, they showed a high anxiety-like response, associated with a blunted increase in corticosterone levels and higher c-Fos activation in the prefrontal cortex. Moreover, these mice also presented a lack of downregulation of hippocampal long-term potentiation after stress exposure. Therefore, higher postsynaptic 5-HT1AR activation might predispose to a high anxious phenotype and an impaired stress coping behavior.},
organization = {Funding sources: This research was supported by Spanish Ministry of Economy and Competitiveness (SAF2011-25020 and SAF2015-67457-R), Instituto de Salud Carlos III (FIS Grant PI13-00038) co-funded by the European Regional Development Fund (‘A way to buildEurope’) and Centro de Investigacion Biomedica en Red de Salud Mental(CIBERSAM).},
publisher = {American Chemical Society},
publisher = {ACS Chem Neurosci. 2017 Nov 15;8(11):2393-2401},
title = {Enhanced Stress Response in 5-HT1AR Overexpressing Mice: Altered HPA Function and Hippocampal Long-Term Potentiation},
author = {Pilar Cuéllar, María Fuencisla and Vidal, Rebeca and Díaz Martínez, Álvaro and Garro Martínez, Emilio and Linge Méndez, Raquel and Castro Fernández, María Elena and Haberzettl, Robert and Fink, Heidrun and Bert, Bettina and Brosda, Jan and Romero Presno, Beatriz and Crespo Facorro, Benedicto and Pazos Carro, Ángel},
}