@article{10902/12997,
year = {2016},
month = {11},
url = {http://hdl.handle.net/10902/12997},
abstract = {Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent Listeria monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1?22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1?22-activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.},
publisher = {Frontiers Research Foundation},
publisher = {Front. Immunol. Nov 2016 7:541},
title = {Biomarker tools to Design Clinical 
Vaccines Determined from a study
 of annual Listeriosis Incidence in
 Northern spain},
author = {Calderón González, Ricardo and Terán Navarro, Héctor and Marimon, José María and González Rico, Claudia and Calvo Montes, Jorge and Frande Cabanes, Elisabet and Alkorta Gurrutxaga, Miriam and Fariñas Álvarez, María del Carmen and Martínez Martínez, Luis and Pérez Trallero, Emilio and Álvarez Domínguez, Carmen},
}