@article{10902/12928,
year = {2018},
month = {4},
url = {http://hdl.handle.net/10902/12928},
abstract = {The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-? (A?1?42 +) (N = 19), and positive phosphorylated tau (N = 18). The A?1?42 + group exhibited thickening of middle temporal regions, while positive phosphorylated tau individuals showed thinning in the superior parietal and orbitofrontal cortices. Subjects with abnormal CSF biomarkers further showed regional white matter atrophy and more segregated cortical networks, the A?1?42 + group showing heightened isolation of cingulate and temporal cortices. Collectively, these findings highlight the relevance of combining structural brain imaging and connectomics for in vivo tracking of Alzheimer's disease lesions in asymptomatic stages.},
organization = {This work was supported by research grants from the Spanish Ministry of Economy and
Competitiveness (SAF2011-25463 to J.L.C., PSI2014-55747-R to M.A.), the Carlos III
Institute of Health, Spain (PI11/02425 and PI14/01126 to J.F.; PI11/3035 and
PI14/1561 to A.L.; PI08/0139, PI12/02288 and PI16/01652 to P.S.J.), jointly funded by
Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, “Una manera de
hacer Europa”, the Joint Programming in Neurodegenerative Disease Research
(DEMTEST to P.S.J.), “Marató TV3” (project 20141210 to J.F. and 20142610 to A.L.),
the Regional Ministry of Innovation, Science and Enterprise, Junta de Andalucia (P12-
CTS-2327 to J.C.L.), and the CIBERNED program (Signal project).},
publisher = {Elsevier},
publisher = {Neurobiology of Aging 

Volume 64, April 2018, Pages 58-67},
title = {Cerebral changes and disrupted gray-matter cortical networks in asymptomatic older
 adults at risk for Alzheimer's disease},
author = {Cantero, José L. and Atienza, Mercedes and Sánchez-Juan, Pascual and Rodríguez Rodríguez, Eloy Manuel and Vázquez Higuera, José Luis and Pozueta Cantudo, Ana and González Suárez, Andrea and Vilaplana, Eduard and Pegueroles, Jordi and Montal, Víctor and Blesa, Rafael and Alcolea, Daniel and Lleo, Alberto and Fortea, Juan},
}