@article{10902/12910,
year = {2017},
month = {2},
url = {http://hdl.handle.net/10902/12910},
abstract = {Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.},
publisher = {Nature Publishing Group},
publisher = {Sci Rep. 2017 Feb 24;7:43263},
title = {Risk Model for Colorectal Cancer 
in Spanish Population Using 
Environmental and Genetic Factors: 
Results from the MCC-Spain study},
author = {Ibáñez Sanz, Gemma and Díez Villanueva, Anna and Alonso, M. Henar and Rodríguez Moranta, Francisco and Pérez Gómez, Beatriz and Bustamante, Mariona and Martin, Vicente and Llorca Díaz, Francisco Javier and Amiano, Pilar and Ardanaz, Eva and Tardón García, Adonina and Jiménez Moleón, José Juan and Peiró Pérez, Rosana and Alguacil, Juan and Navarro, Carmen and Guinó, Elisabet and Binefa, Gemma and Fernández Navarro, Pablo and Espinosa, Anna and Palazuelos Calderón, Camilo},
}