@article{10902/11931,
year = {2017},
url = {http://hdl.handle.net/10902/11931},
abstract = {Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during the coming years. However, the fragmented vision of their side effects and toxicity in humans has proscribed their use as nanomedicines. Most studies agree that biocompatibility depends on the state of aggregation/dispersion of CNTs under physiological conditions, but conclusions are confusing so far. This study designs an experimental setup to investigate the cytotoxic effect of individualized multiwalled CNTs compared to that of identical nanotubes assembled on submicrometric structures. Our results demonstrate how CNT cytotoxicity is directly dependent on the nanotube dispersion at a given dosage. When CNTs are gathered onto silica templates, they do not interfere with cell proliferation or survival becoming highly compatible. These results support the hypothesis that CNT cytotoxicity is due to the biomimetics of these nanomaterials with the intracellular nanofilaments. These findings provide major clues for the development of innocuous CNT-containing nanodevices and nanomedicines.},
organization = {Acknowledgments: This work was supported by the Spanish MINECO Project (references PI13/01074, PI16/00496 and CTM2014–58481-R, IDIVAL INNVAL15/15), Xunta de Galicia (Centro Singular de Investigación de Galicia-Accreditation 2016–2019 and 
EM2014/035), European Regional Development Fund – ERDF and Fundación Tatiana Pérez de Guzmán El Bueno.},
publisher = {Dove Medical Press},
publisher = {International Journal of Nanomedicine, 2017, 12, 6317-6328},
title = {Carbon nanotubes gathered onto silica particles lose their biomimetic properties with the cytoskeleton becoming biocompatible},
author = {González Domínguez, Elena and Iturrioz Rodríguez, Nerea and Padín González, Esperanza and Villegas Sordo, Juan Carlos and García Hevia, Lorena and Pérez Lorenzo, Moisés and Parak, Wolfgang J. and Correa Duarte, Miguel A. and López Fanarraga, Mónica},
}