@article{10902/1146,
year = {2010},
month = {7},
url = {http://hdl.handle.net/10902/1146},
abstract = {Despite its fundamental role in centrosome biology, procentriole formation both in the
canonical and in the de novo replication pathways remains poorly understood, and the
molecular components that are involved in human cells are not well established. We found
that one of the tubulin cofactors, TBCD, is localized at centrosomes and the midbody,
and is required for spindle organization, cell abscission, centriole formation, and
ciliogenesis. Thus, we have established a molecular link between the centriole and the
midbody, demonstrating that this cofactor is also necessary for microtubule retraction
during cell abscission. TBCD is the first centriolar protein identified that plays a role in
the assembly of both “centriolar rosettes” during early ciliogenesis, and at the procentriole
budding site by S/G2, a discovery that directly implicates tubulin cofactors in the cell
division, cell migration, and cell signaling research fields.},
publisher = {Landes Bioscience},
publisher = {Communicative and Integrative Biology. 2010 Jul;3(4):306-8.},
title = {Emerging roles for tubulin folding cofactors at the centrosome},
author = {López Fanarraga, Mónica and Carranza Ferrer, Gerardo and Castaño Cobo, Raquel and Jiménez, Victoria and Villegas Sordo, Juan Carlos and Zabala Otaño, Juan Carlos},
}