@article{10902/11385,
year = {2016},
url = {http://hdl.handle.net/10902/11385},
abstract = {Tropheryma whipplei endocarditis is an uncommon condition with very few series and<90 cases reported in the literature. The aim of the study was to analyze the epidemiological, clinical, and outcome characteristics of 17 cases of T. whipplei endocarditis recruited in our country from a multicentric cohort from 25 Spanish hospitals from the Spanish Collaboration on Endocarditis?Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España. From a total of 3165 cases included in the cohort, 14.2% were diagnosed of blood culture negative endocarditis (BCNE) and 3.5% of these had T. whipplei endocarditis. This condition was more frequent in men. The average age was 60.3 years. Previous cardiac condition was present in 35.3% of the cases. The main clinical manifestation was cardiac failure (76.5%) while fever was only present in the 35.3%. Ecocardiography showed vegetations in 64.7% of patients. Surgery was performed in all but 1 cases and it allowed the diagnosis when molecular assays were performed. A broad range rRNA 16S polymerase chain reaction was used for first instance in all laboratories and different specific targets for T. whipplei were employed for confirmation. A concomitant Whipple disease was diagnosed in 11.9% of patients. All patients received specific antimicrobial treatment for at least 1 year, with no relapse and complete recovery. T. whipplei endocarditis is an uncommon condition with an atypical presentation that must be considered in the diagnosis of BCNE. The prognosis is very good when an appropriate surgical management and antimicrobial-specific treatment is given.},
publisher = {Lippincott Williams & Wilkins},
publisher = {Medicine (2016) 95:26(e4058)},
title = {Tropheryma whipplei endocarditis in Spain Case reports of 17 prospective cases},
author = {García Álvarez, Lara and Sanz, María Mercedes and Marín, Mercedes and Fariñas Álvarez, María del Carmen and Armiñanzas Castillo, Carlos and Arnaiz García, Ana María and Berrazueta Fernández, José Ramón and Bellisco, Sara and Cobo Belaustegui, Manuel and Durán, Raquel and Fariñas Álvarez, María Concepción and Fernández Mazarrasa, Carlos and Gómez Izquierdo, Rubén and González Rico, Claudia and Gutiérrez Díez, José Francisco and Martín Durán, Rafael and Pajarón, Marcos and Parra Blanco, José Antonio and Teira Cobo, Ramón María and Zarauza Navarro, Manuel Jesús},
}