@article{10902/1088,
year = {2012},
month = {3},
url = {http://hdl.handle.net/10902/1088},
abstract = {CD38, a type II transmembrane glycoprotein expressed in many cells of the immune system, is involved in cell signaling, migration and differentiation. Studies in CD38 deficient mice (CD38 KO mice) indicate that this molecule controls inflammatory immune responses, although its involvement in these responses depends on the disease model analyzed. Here, we explored the role of CD38 in the control of autoimmune responses using chicken collagen type II (col II) immunized C57BL/6-CD38 KO mice as a model of collagen-induced arthritis (CIA). We demonstrate that CD38 KO mice develop an attenuated CIA that is accompanied by a limited joint induction of IL-1β and IL-6 expression, by the lack of induction of IFNγ expression in the joints and by a reduction in the percentages of invariant NKT (iNKT) cells in the spleen. Immunized CD38 KO mice produce high levels of circulating IgG1 and low of IgG2a anti-col II antibodies in association with reduced percentages of Th1 cells in the draining lymph nodes. Altogether, our results show that CD38 participates in the pathogenesis of CIA controlling the number of iNKT cells and promoting Th1 inflammatory responses.},
organization = {This work was supported by grants from the Ministerio de Ciencia e Innovación, Spain to RM (SAF2008-02042 and SAF2011-22463), JM (BFU2009-07206) and JS and MZ (SAF-2008-03685, SAF2011-27261), from the Fundación Marqués de Valdecilla-Leonardo Torres Quevedo, Spain to JM and RM (FMV-UC 08/02), from the European Commission-European Regional Development Fund (ERDF/FEDER), in collaboration with ISCIII-FIS06/1502 (MZ), from the Junta de Andalucía, Consejería de Economía, Innovación y Ciencia to JS and MZ (CVI-226, and PC08-CTS-04046) and from Fundación Eugenio Rodríguez Pascual to RM. SGR is supported by a JAE-Doc-CSIC-Contract and ARV is recipient of a Fellowship-Contract from the Junta de Andalucía. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.},
publisher = {Public Library of Science},
publisher = {PLoS One, 2012, 7(3), e33534},
title = {Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis},
author = {Postigo Fernández, Jorge and Iglesias Lozano, Marcos and Cerezo Wallis, Daniela and Rosal Vela, Antonio and García Rodríguez, Sonia and Zubiaur, Mercedes and Sancho, Jaime and Merino Pérez, Ramón and Merino Pérez, Jesús},
}