@article{10902/10443,
year = {2014},
url = {http://hdl.handle.net/10902/10443},
abstract = {Objective: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children but it is not exceptional in adults. Increased familial occurrence supports a genetic predisposition for HSP. In this context, an association with the human leukocyte antigen-HLA-DRB1*01 phenotype has been suggested in Caucasian individuals with HSP. However, data on the potential association of HSP with HLA-DRB1*01 were based on small case series. To further investigate this issue, we performed HLA-DRB1 genotyping of the largest series of HSP patients ever assessed for genetic studies in Caucasians. Methods: 342 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al classification criteria, and 303 sex and ethnically matched controls were assessed. HLA-DRB1 alleles were determined using a PCR-Sequence-Specific-Oligonucleotide Probe (PCR-SSOP) method. Results: A statistically significant increase of HLA-DRB1*01 in HSP patients when compared with controls was found (43% vs 7%, respectively; p<0.001; odds ratio-OR=2.03 [1.43-2.87]). It was due to the increased frequency of HLA-DRB1*0103 phenotype in HSP (14% vs 2%; p<0.001; OR=8.27 [3.46-23.9]). These results remained statistically significant after adjusting for Bonferroni correction. In contrast, a statistically significant decreased frequency of the HLA-DRB1*0301 phenotype was observed in patients compared to controls (5.6% vs 18.1%, respectively; p<0.001, OR=0.26 [0.14-0.47]), even after adjustment for Bonferroni correction. No HLA-DRB1 association with specific features of the disease was found. Conclusion: Our study confirms an association of HSP with HLA-DRB1*01 in Caucasians. Also, a protective effect against the development of HSP appears to exist in Caucasians carrying the HLA-DRB1*03 phenotype.},
publisher = {John Wiley and Sons Ltd},
publisher = {Arthritis and rheumatology Vol. 67, No. 3, March 2015, pp 823–827},
title = {HLA-DRB1 association with Henoch-Schonlein purpura},
author = {López Mejías, Raquel and Genre, Fernanda and Pérez, BS and Castañeda, S and Ortego Centeno, N and Llorca Díaz, Francisco Javier and Ubilla García, Begoña and Remuzgo Martínez, Sara and Mijares Díaz, Verónica and Pina Murcia, Trinitario and Calvo Río, V and Márquez, A and Sala, Icardo and Miranda Filloy, José Alberto and Conde Jaldón, M and Ortíz Fernández, L and Rubio, E and León Luque, M and Blanco Madrigal, JM and Galíndez Aguirregoikoa, Eva and González Vela, MC and Ocejo Vinyals, JG and González Escribano, F and Martín, J and Blanco Alonso, Ricardo and González-Gay Mantecón, Miguel Ángel},
}